Depauperate \De*pau"per*ate\, v. t. & i. [imp. & p. p. {Depauperated}; p. pr. & vb. n. {Depauperating}.] [LL. depauperatus, p. p. depauperare to impoverish; L. de- + pauperare to make poor, pauper poor.] To make poor; to impoverish. Liming does not depauperate; the ground will last long, and bear large grain. --Mortimer. Humility of mind which depauperates the spirit. --Jer. Taylor.