Knuckle \Knuc"kle\, v. i. [imp. & p. p. {Knuckled};; p. pr. & vb. n. {Knuckling}.] To yield; to submit; -- used with down, to, or under. {To knuckle to}. (a) To submit to in a contest; to yield to. [Colloq.] See {To knock under}, under {Knock}, v. i. (b) To apply one's self vigorously or earnestly to; as, to knuckle to work. [Colloq.]