Ossify \Os"si*fy\, v. t. [imp. & p. p. {Ossified}; p. pr. & vb. n. {Ossifying}.] [L. os, ossis, bone + -fy: cf. F. ossifier. See {Osseous}.] 1. (Physiol.) To form into bone; to change from a soft animal substance into bone, as by the deposition of lime salts. 2. Fig.: To harden; as, to ossify the heart. --Ruskin. Ossifying \Os"si*fy`ing\, a. (Physiol.) Changing into bone; becoming bone; as, the ossifying process.