Plague \Plague\, v. t. [imp. & p. p. {Plagued}; p. pr. & vb. n. {Plaguing}.] 1. To infest or afflict with disease, calamity, or natural evil of any kind. Thus were they plagued And worn with famine. --Milton. 2. Fig.: To vex; to tease; to harass. She will plague the man that loves her most. --Spenser. Syn: To vex; torment; distress; afflict; harass; annoy; tease; tantalize; trouble; molest; embarrass; perplex.