Source : Webster's Revised Unabridged Dictionary (1913)

Despite \De*spite"\, v. t. [imp. & p. p. {Despited}; p. pr. &
   vb. n. {Despiting}.] [OF. despitier, fr. L. despectare,
   intens. of despicere. See {Despite}, n.]
   To vex; to annoy; to offend contemptuously. [Obs.] --Sir W.
   Raleigh.

Despite \De*spite"\, prep.
   In spite of; against, or in defiance of; notwithstanding; as,
   despite his prejudices.

   Syn: See {Notwithstanding}.

Despite \De*spite"\, n. [OF. despit, F. d['e]pit, fr. L.
   despectus contempt, fr. despicere. See {Despise}, and cf.
   {Spite}, {Despect}.]
   1. Malice; malignity; spite; malicious anger; contemptuous
      hate.

            With all thy despite against the land of Israel.
                                                  --Ezek. xxv.
                                                  6.

   2. An act of malice, hatred, or defiance; contemptuous
      defiance; a deed of contempt.

            A despite done against the Most High. --Milton.

   {In despite}, in defiance of another's power or inclination.
      

   {In despite of}, in defiance of; in spite of. See under
      {Spite}. ``Seized my hand in despite of my efforts to the
      contrary.'' --W. Irving.

   {In your despite}, in defiance or contempt of you; in spite
      of you. [Obs.]

Source : WordNet®

despite
     n 1: lack of respect accompanied by a feeling of intense dislike;
          "he was held in contempt"; "the despite in which
          outsiders were held is legendary" [syn: {contempt}, {disdain},
           {scorn}]
     2: contemptuous disregard; "she wanted neither favor nor
        despite"