Source : Webster's Revised Unabridged Dictionary (1913)

Malediction \Mal`e*dic"tion\, n. [L. maledictio: cf. F.
   mal['e]diction. See {Maledicent}.]
   A proclaiming of evil against some one; a cursing;
   imprecation; a curse or execration; -- opposed to
   {benediction}.

         No malediction falls from his tongue.    --Longfellow.

   Syn: Cursing; curse; execration; imprecation; denunciation;
        anathema.

   Usage: {Malediction}, {Curse}, {Imprecation}, {Execration}.
          Malediction is the most general term, denoting bitter
          reproach, or wishes and predictions of evil. Curse
          implies the desire or threat of evil, declared upon
          oath or in the most solemn manner. Imprecation is
          literally the praying down of evil upon a person.
          Execration is literally a putting under the ban of
          excommunication, a curse which excludes from the
          kingdom of God. In ordinary usage, the last three
          words describe profane swearing, execration being the
          strongest.

Source : WordNet®

malediction
     n : the act of calling down a curse that invokes evil (and
         usually serves as an insult); "he suffered the
         imprecations of the mob" [syn: {imprecation}]