Source : Webster's Revised Unabridged Dictionary (1913)

Manuscript \Man"u*script\, a. [L. manu scriptus. See {Manual},
   and {Scribe}.]
   Written with or by the hand; not printed; as, a manuscript
   volume.

Manuscript \Man"u*script\, n. [LL. manuscriptum, lit., something
   written with the hand. See {Manuscript}, a.]
   1. A literary or musical composition written with the hand,
      as distinguished from a printed copy.

   2. Writing, as opposed to print; as, the book exists only in
      manuscript. --Craik.

   Note: The word is often abbreviated to MS., plural MSS.

Source : WordNet®

manuscript
     n 1: the form of a literary work submitted for publication [syn:
          {ms}]
     2: handwritten book or document [syn: {holograph}]