Source : Webster's Revised Unabridged Dictionary (1913)

Misfortune \Mis*for"tune\, n.
   Bad fortune or luck; calamity; an evil accident; disaster;
   mishap; mischance.

         Consider why the change was wrought, You 'll find his
         misfortune, not his fault.               --Addison.

   Syn: Calamity; mishap; mischance; misadventure; ill; harm;
        disaster. See {Calamity}.

Misfortune \Mis*for"tune\, v. i.
   To happen unluckily or unfortunately; to miscarry; to fail.
   [Obs.] --Stow.

Source : WordNet®

misfortune
     n 1: unnecessary and unforeseen trouble resulting from an
          unfortunate event [syn: {bad luck}]
     2: an unfortunate state resulting from unfavorable outcomes
        [syn: {bad luck}, {tough luck}, {ill luck}] [ant: {good
        fortune}, {good fortune}]