St. Louis n 1: the largest city in Missouri; a busy river port on the Mississippi River near its confluence with the Missouri River; was an important staging area for wagon trains westward in the 19th century [syn: {Saint Louis}, {Gateway to the West}] 2: king of France and son of Louis VIII; he led two unsuccessful crusades; considered an ideal medieval king (1214-1270) [syn: {Louis IX}, {Saint Louis}]