Source : Webster's Revised Unabridged Dictionary (1913)

Botheration \Both`er*a"tion\, n.
   The act of bothering, or state of being bothered; cause of
   trouble; perplexity; annoyance; vexation. [Colloq.]

Source : WordNet®

botheration
     n 1: the psychological state of being irritated or annoyed [syn:
          {irritation}, {annoyance}, {vexation}]
     2: something or someone that causes trouble; a source of
        unhappiness; "washing dishes was a nuisance before we got
        a dish washer"; "a bit of a bother"; "he's not a friend,
        he's an infliction" [syn: {annoyance}, {bother}, {pain}, {infliction},
         {pain in the neck}, {pain in the ass}]