Source : Webster's Revised Unabridged Dictionary (1913)

Self-destruction \Self`-de*struc"tion\, n.
   The destruction of one's self; self-murder; suicide.
   --Milton.

Source : WordNet®

self-destruction
     n 1: the act of killing yourself; "it is a crime to commit
          suicide" [syn: {suicide}, {self-annihilation}]
     2: the act of destroying yourself; "his insistence was pure
        self-destruction"