Source : Webster's Revised Unabridged Dictionary (1913)

Systemic \Sys*tem"ic\, a.
   1. Of or relating to a system; common to a system; as, the
      systemic circulation of the blood.

   2. (Anat. & Physiol.) Of or pertaining to the general system,
      or the body as a whole; as, systemic death, in distinction
      from local death; systemic circulation, in distinction
      from pulmonic circulation; systemic diseases.

   {Systemic death}. See the Note under {Death}, n., 1.

Source : WordNet®

systemic
     adj : affecting an entire system; "a systemic poison"