Disease \Dis*ease"\, v. t. [imp. & p. p. {Diseased}; p. pr. & vb. n. {Diseasing}.] 1. To deprive of ease; to disquiet; to trouble; to distress. [Obs.] His double burden did him sore disease. --Spenser. 2. To derange the vital functions of; to afflict with disease or sickness; to disorder; -- used almost exclusively in the participle diseased. He was diseased in body and mind. --Macaulay.