Source : Webster's Revised Unabridged Dictionary (1913)

Despondence \De*spond"ence\, n.
   Despondency.

         The people, when once infected, lose their relish for
         happiness [and] saunter about with looks of
         despondence.                             --Goldsmith.

Source : WordNet®

despondence
     n : feeling downcast and disheartened and hopeless [syn: {despondency},
          {heartsickness}, {disconsolateness}]