Source : Webster's Revised Unabridged Dictionary (1913)

Plague \Plague\, n. [L. plaga a blow, stroke, plague; akin to
   Gr. ?, fr. ? to strike; cf. L. plangere to strike, beat. Cf.
   {Plaint}.]
   1. That which smites, wounds, or troubles; a blow; a
      calamity; any afflictive evil or torment; a great trail or
      vexation. --Shak.

            And men blasphemed God for the plague of hail.
                                                  --Wyclif.

            The different plague of each calamity. --Shak.

   2. (Med.) An acute malignant contagious fever, that often
      prevails in Egypt, Syria, and Turkey, and has at times
      visited the large cities of Europe with frightful
      mortality; hence, any pestilence; as, the great London
      plague. ``A plague upon the people fell.'' --Tennyson.

   {Cattle plague}. See {Rinderpest}.

   {Plague mark}, {Plague spot}, a spot or mark of the plague;
      hence, a token of something incurable.

Plague \Plague\, v. t. [imp. & p. p. {Plagued}; p. pr. & vb. n.
   {Plaguing}.]
   1. To infest or afflict with disease, calamity, or natural
      evil of any kind.

            Thus were they plagued And worn with famine.
                                                  --Milton.

   2. Fig.: To vex; to tease; to harass.

            She will plague the man that loves her most.
                                                  --Spenser.

   Syn: To vex; torment; distress; afflict; harass; annoy;
        tease; tantalize; trouble; molest; embarrass; perplex.

Source : WordNet®

plague
     n 1: a serious (sometimes fatal) infection of rodents caused by
          Yersinia pestis and accidentally transmitted to humans
          by the bite of an infected rat flea (especially bubonic
          plague)
     2: any epidemic disease with a high death rate [syn: {pestilence}]
     3: a swarm of insects that attack plants; "a plague of
        grasshoppers" [syn: {infestation}]
     4: any large scale calamity (especially when thought to be sent
        by God)
     5: an annoyance; "those children are a damn plague"

plague
     v 1: cause to suffer a blight; "Too much rain may blight the
          garden with mold" [syn: {blight}]
     2: annoy continually or chronically; "He is known to harry his
        staff when he is overworked"; "This man harasses his
        female co-workers" [syn: {harass}, {hassle}, {harry}, {chivy},
         {chivvy}, {chevy}, {chevvy}, {beset}, {molest}, {provoke}]